unfoldedproteinresponse相关论文
Unfolded protein response(UPR)is a stress response that is specific to the endoplasmic re-ticulum(ER).UPR is activated u......
Cancer cells are often exposed to cell intrinsic stresses and environmental perturbations that may lead to accumulation ......
Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-in
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Alterations of hHrd1 expression are related to hyperphosphorylated tau in the hippocampus in Alzheim
The degradation of aberrantly phosphorylated tau in neurons plays an important role in the pathogenesis of Alzheimers di......
Study on the combination effects of siPERK and siATF4 on cell growth and apoptosis in cartilage deve
We previously report that BMP2 mediates mild ER stress.The mammalian unfolded protein response (UPR) protects the cell a......
XBP1S,a BMP2-inducible transcription factor,Accelerates Endochondral Bone Growth by activating GEP G
We reported earlier that transcription factor XBP1S binds to RUNX2 and enhances chondrocyte hypertrophy through function......
Normal folding requires that unique conditions be maintained within the ER lumen,and nascent proteins are initially boun......
Protein folding is a fundamental process in eukaryotic cells.When unfolded or misfolded proteins accumulate in the endop......
Severe Endoplasmic Reticulum Stress Response Predicts the Occurrence of Hepatitis B Virus-related Ac
Background Although endoplasmic reticulum(ER)stress is critical in various liver diseases,its role in acute-on-chronic l......
Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomyc
Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals.Neverthe......
PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevi
Pmt1p is an important member of the protein O-mannosyltransferase (PMT) family of enzymes, which participates in the end......
XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHO
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Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the S
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神经退行性疾病是一类常见的神经系统疾病，严重影响患者的生活质量甚至生命安全，因而其发病机理受到人们越来越多的关注。通过对内质......
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Old astrocyte specifically induced substance (OASIS) is an endoplasmic reticulum (ER) stress transducer specifically exp......
胰腺β细胞功能障碍导致糖尿病发生，在糖尿病早期，胰腺β细胞通过自身调节代偿高血糖和外周胰岛素抵抗，涉及的信号通路之一称为未折叠......
目的观察染氟成骨细胞未折叠蛋白反应肌醇酶1 (IRE1）-Xbp1信号通路的表达及siRNA干扰抑制IREl表达后成骨细胞内成骨细胞标志物的变......
砷暴露会给人体带来健康隐患，也可通过诱导细胞凋亡治疗一些疾病，这都是砷的毒性发挥的作用，但其作用机制尚不明确。目前研究显示，内质......
目的研究未折叠蛋白反应在正常和发育不良性髋臼软骨发育中的影响。方法通过新生大鼠伸髋伸膝位模拟婴儿襁褓体位制作发育不良髋臼......
心血管疾病是糖尿病患者的主要死因，然而糖尿病并发动脉粥样硬化的分子和细胞机制现在仍未明确。内质网应激可能在高血糖、糖尿病与......
As small heat shock proteins,α-crystallins function as molecular chaperones and inhibit the misfolding and aggregation ......
